I'm running vista and it works fine for me, although sometimes I have to go into options and check a different voice and then recheck kate or paul. Microsoft Mary wants to take over I think because I never have a problem with her. The Neospeech voices installed on hals first page instead of as it's own program on C drive like Cepstrall voices. I don't know if that was any real help for you except to say it does work with vista.