Personally, I think that unless the conversation is more definitive with regard to identifying the subject, the meaning will become lost and meaningless.
Pronouns like I, he, she, you, it, we, they, this or that that are used without a noun (person, place or thing), will usually become vague unless referred in either a follow up remark or the previous sentence.
As much difficulty as humans have with these, I can only imagine how it would add to the horror when applied to chatbots or AI programs.
Same thing with confusing subjects like "I ran after a monkey wearing pajamas."
Just who's pajamas were they?
Maybe some of the responses could reiterate the previous subject like "Yeah, that TV show about Funniest Animals was the best."
You could also allow the bot to quiz the user like, "Yes, it appears that you really like that TV show. What's it called again? or similar.
I guess there is no "One size response fits all" situation but in making several random responses, make them generic enough so that they could possibly apply to any number of statements.
Maybe some more examples from you might help to draw some additional comments from members or visitors.