I don't think Misterhouse works with Windows 10. I'm not sure that it is supported by anyone or forum, given it's age.
Girder was sort of an event driven,scripted,automation programming language. Don't know the status of it either but I'm certain it's rather dated.
So it's anyone's guess at this point. There are many other automation program available that might do what you require as well as some easy programming languages to employ.
Good luck!